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- Magic cancer bullet : how a tiny orange pill is rewriting medical history / by Vasella, Daniel.(CARDINAL)673586; Slater, Robert,1943-2014.(CARDINAL)517413;
MARCIVE 03/01/06- Subjects: Imatinib.; Tumors; Piperazines;
- Available copies: 2 / Total copies: 2
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- The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level / by Wapner, Jessica.(CARDINAL)402729; Weinberg, Robert A.(Robert Allan),1942-(CARDINAL)731563;
Includes bibliographical references (pages 283-290) and index.Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time.This work focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this astounding publication.- Subjects: Hungerford, David S., 1938-; Chronic myeloid leukemia; Chronic myeloid leukemia; Cancer; Cancer; Mutation (Biology); Imatinib.;
- Available copies: 4 / Total copies: 4
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Results 1 to 2 of 2